Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo
✍ Scribed by Martin P. Meyer; Jonathan D.W. Clarke; Ketan Patel; Andrea Townsend-Nicholson; Geoffrey Burnstock
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 768 KB
- Volume
- 214
- Category
- Article
- ISSN
- 1058-8388
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✦ Synopsis
Responses to extracellular nucleotides (e.g., ATP, ADP, etc.) have been demonstrated in a number of embryonic cell types suggesting they may be important signalling molecules during embryonic development. Here the authors describe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y 1 (cP2Y 1 ), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y 1 is expressed in a developmentally regulated manner in the limb buds, mesonephros, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems.