𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Selective ET A Antagonists. 5. Discovery and Structure−Activity Relationships of Phenoxyphenylacetic Acid Derivatives

✍ Scribed by Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Iain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.


Book ID
126018911
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
294 KB
Volume
43
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Discovery and structure–activity relatio
✍ Muna H. Abdi; Paul J. Beswick; Andy Billinton; Laura J. Chambers; Andrew Charlto 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 720 KB

A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X(7) receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and compound 31 was identified as a potent P2X(7) antagonist with excellen