Synthesis and deuterium labelling of the
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Jean-Yves Sancéau; Denis Larouche; Brigitte Caron; Patrick Bélanger; Agnès Coque
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Article
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2007
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John Wiley and Sons
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French
⚖ 202 KB
Acolbifene (EM-652 Á HCl, SCH 57068 Á HCl), a highly potent and orally active selective estrogen receptor modulator (SERM), is at late stage clinical development for the treatment of estrogen-sensitive breast cancer. Acolbifene-7-glucuronide 1 (major) and acolbifene-4 0 -glucuronide 2 (minor) were i