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Selective estrogen-receptor modulation by Tofupill, a unique phyto-SERM for menopausal treatment

✍ Scribed by Israel Yoles; Benjamin Chayen


Book ID
117191558
Publisher
Lippincott Williams and Wilkins
Year
2003
Tongue
English
Weight
62 KB
Volume
101
Category
Article
ISSN
0029-7844

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The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coumestrol converts this estrogen agonist into an anta