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Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

✍ Scribed by Leif Dahlberg; R. Clark Billinghurst; Paul Manner; Fred Nelson; Ginette Webb; Mirela Ionescu; Agnes Reiner; Michael Tanzer; David Zukor; Jeffrey Chen; Harold E. Van Wart; A. Robin Poole

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 485 KB
Volume: 43
Category: Article
ISSN: 0004-3591
DOI: 10.1002/1529-0131(200003)43:3<673::aid-anr25>3.0.co;2-8

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Sites of collagenase cleavage and denatu

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

✍ William Wu; R. Clark Billinghurst; Isabelle Pidoux; John Antoniou; David Zukor; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 709 KB

## Objective: To determine the sites of cleavage and denaturation of type ii collagen (cii) by collagenase(s) in healthy and osteoarthritic (oa) human articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 (mmp-1) and mmp-13. ## Methods: Single (per subject)