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Selective elimination of malaria infected erythrocytes by a modified phospholipase A2 in vitro

✍ Scribed by Gert N. Moll; Henri J. Vial; Frans C. van der Wiele; Marie-Laure Ancelin; Ben Roelofsen; Arend J. Slotboom; Gerard H. de Haas; Laurens L.M. van Deenen; Jos A.F. Op den Kamp


Book ID
115729413
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
396 KB
Volume
1024
Category
Article
ISSN
0005-2736

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To establish the dose dependency of phospholipase A 2 (PLA 2 ) inhibition by the organophosphorus compound (OPC) paraoxon (POX), human platelet membranes were incubated after Ca 2+ removal (to inactivate the PLA 2 ) with 0.3, 1 and 3 g ml ؊1 POX for 5, 30 and 60 min each. The PLA 2 activity (pmol mg