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Selective down-regulation of angiotensin II receptor type 1A signaling by protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells

โœ Scribed by Thanh Doan; Paul Farmer; Thomas Cooney; M.Showkat Ali


Book ID
113527554
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
715 KB
Volume
16
Category
Article
ISSN
0898-6568

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## Abstract Angiotensin II is an octapeptide that regulates diverse cellular responses including the actin cytoskeletal organization. In this study, stable cell lines overexpressing wildโ€type or catalytically inactive SHPโ€2 were employed to elucidate the signaling pathway utilized by the SHPโ€2 tyro