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Selective dopamine receptors: Synthesis, complexing properties, and molecular modelling studies of new podands derived from 4-hydroxy-1H-pyrazole

✍ Scribed by María Isabel Rodríguez-Franco; Patricia San Lorenzo; Ana Martínez; Pilar Navarro

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 787 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00047-2

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✦ Synopsis

New podands derived from 4-hydroxy-lH-pyrazole have been prepared. Their complexing properties towards cations (Na +, K +, NH4 +) and some neurotransmitters (doparnine and norepinephrine) have been studied, using biphasic extraction experiments, molecular modelling, and a NMR titration. Podand 10, 1-benzyl-4-hydroxy-3,5-bis(2, 5, 8, 11-tetraoxadodecan-l-yl)-lH-pyrazole, showed an interesting selective complexation of dopamine.

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