Selective dimethyldioxirane oxidation of bile acid methyl esters

✍ Scribed by P.Christopher Buxton; Brian A. Marples; Richard C. Toon; Victoria L. Waddington

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 247 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00834-5

✦ Synopsis

DMDO oxidation of the hydroxy groups of bile acid methyl esters establishes the positional order of reactivity as 3-7 > 6 > 12 and supports a mechanism involving C-H oxygen insertion through a planar intramolecularly hydrogen bonded transition state.