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Selective Determination of Native Fluorescent Bioamines through Precolumn Derivatization and Liquid Chromatography Using Intramolecular Fluorescence Resonance Energy Transfer Detection

✍ Scribed by Yoshitake, Makoto; Nohta, Hitoshi; Yoshida, Hideyuki; Yoshitake, Takashi; Todoroki, Kenichiro; Yamaguchi, Masatoshi


Book ID
118025003
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
373 KB
Volume
78
Category
Article
ISSN
0003-2700

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## Abstract A rapid and sensitive HPLC enantioselective method with fluorescence detection was developed to determine (−)‐(__R__) and (+)‐(__S__) enantiomers of the metabolites of citalopram, demethyl‐ and didemethyl‐citalopram in plasma and brain tissue. This assay involves pre‐column chiral deriv