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Selective detachment of Boc-protected amino acids and peptides from Merrifield, PAM and Wang resins by trimethyltin hydroxide

✍ Scribed by Ricardo L.E. Furlán; Ernesto G. Mata; Oreste A. Mascaretti; Clara Peña; Marcelo P. Coba

Book ID: 104208873
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 753 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00805-9

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✦ Synopsis

We describe the development of a new non-acidolytic and non-nucleophilic method for the selective cleavage by trimethyltin hydroxide of amino acids and dipeptides at benzyl ester links attached to resins commonly used in peptide synthesis.

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