Selective degradation of histidine residue mediated by copper(II)-catalyzed autoxidation of glycated peptide (Amadori compound)

Selective cleavage of an azaGly peptide

Selective cleavage of an azaGly peptide bond by copper(II). Long-range effect of histidine residue

✍ Reda Mhidia; Oleg Melnyk 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 359 KB

## Abstract Several reports have highlighted the interest of replacing Gly, a frequent amino acid within bioactive peptides, by azaGly (Agly) to improve their stability, activity or for the design of prodrugs. Because metal catalysis is increasingly used for tailoring peptide molecules, we have stu