Selective deficiency of CD4+/CD45RA+ lymphocytes in patients with ataxia-telangiectasia
โ Scribed by Roberto Paganelli; Enrico Scala; Elisa Scarselli; Claudio Ortolani; Andrea Cossarizza; Daniela Carmini; Fernando Aiuti; Massimo Fiorilli
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 942 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0271-9142
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## Fredericko and Division of Tumor Immunology, Dana-Farber Cancer Institute, Cambridgen Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes\* Flow cytometric analysis of human peripheral blood T lymphocytes
## Abstract Ataxia telangiectasia (AT) is a human autosomal recessive disorder in which patients show a marked predisposition to malignant disease and cytogenetic abnormalities. We report here the levels of spontaneously occurring chromosome aberrations and particularly the presence of cytogenetica
Background. Patients with ataxia-telangiectasia (A-T) are at an increased risk for developing lymphoid malignancies, yet the appropriate therapy remains unknown. Radiation therapy at conventional doses results in destruction of normal tissue, which has suggested that full-dose chemotherapy might res