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Selective cytotoxic effects of a ricin A chain immunotoxin made with the monoclonal antibody SWA11 recognising a human small cell lung cancer antigen


Book ID
121996255
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
167 KB
Volume
7
Category
Article
ISSN
0169-5002

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## Abstract The monoclonal antibody (MAb) SEN3I, a mouse IgG~1~ which recognizes the cluster‐5a antigen on small‐cell lung cancer (SCLC) cells, was used to prepare a selective and potent blocked ricin immunotoxin. In a series of experiments __in__ vitro and in a SCLC xenograft model in nude mice, t