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Selective Catalytic Reductions of Amides and Nitriles to Amines

✍ Scribed by Shoubhik Das; Shaolin Zhou; Daniele Addis; Stephan Enthaler; Kathrin Junge; Matthias Beller


Book ID
106549799
Publisher
Springer
Year
2010
Tongue
English
Weight
469 KB
Volume
53
Category
Article
ISSN
1022-5528

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πŸ“œ SIMILAR VOLUMES


Selective reduction of secondary amides
✍ Byung H. Lee; Michael F. Clothier πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 89 KB

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.