Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation
β Scribed by James T. Taylor; Luping Huang; Jonathan E. Pottle; Kai Liu; Yali Yang; Xiangbin Zeng; Brian M. Keyser; Krishna C. Agrawal; J. Bondo Hansen; Ming Li
- Book ID
- 116334763
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 487 KB
- Volume
- 267
- Category
- Article
- ISSN
- 0304-3835
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## Abstract Channels formed by the canonical transient receptor potential (TRPC) subfamily of proteins are Ca^2+^βpermeable, nonselective cation channels with various functions. Through a phospholipase C (PLC)βdependent mechanism TRPC6, a member of TRPC subfamily, can be activated by receptor tyros
In studies on the apical membranes of cultured MCF-7 human breast carcinoma cells, we found two conspicuous K Β§ channel types with conductances of 23 and 70 pS, respectively. Of these, the 23-pS K Β§ channel was most conspicuous. In cell-attached patches with KC1 in the pipette, it had a linear curre