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Selective base-pair destabilization enhances binding of a DNA methyltransferase

โœ Scribed by Daniel A. Erlanson; Scot A. Wolfe; Lin Chen; Gregory L. Verdine


Book ID
108378713
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
829 KB
Volume
53
Category
Article
ISSN
0040-4020

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Two nucleoside derivatives containing the base analogues 3-deazaadenine and 3-methyl-2-pyridone have been prepared as analogues of dA and dT, respectively. After conversion into the appropriately protected phosphoramidites, DNA sequences were prepared with site-specifically placed analogues. When pr