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Selective backbone labeling of proteins using {1,2-13C2}-pyruvate as carbon source

✍ Scribed by Chenyun Guo; Chun Geng; Vitali Tugarinov


Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
398 KB
Volume
44
Category
Article
ISSN
0925-2738

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HIV-1 protease (HIV-1 PR), which is encoded by retroviruses, is required for the processing of gag and pol polyprotein precursors, hence it is essential for the production of infectious viral particles. In vitro inhibition of the enzyme results in the production of progeny virions that are immature