Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer

Nuclear estrogen receptor targeted photo

Nuclear estrogen receptor targeted photodynamic therapy: Selective uptake and killing of MCF-7 breast cancer cells by a C17α-alkynylestradiol-porphyrin conjugate

✍ Narasimha Swamy; Ajay Purohit; Ana Fernandez-Gacio; Graham B. Jones; Rahul Ray 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

## Abstract We hypothesized that over‐expression of estrogen receptor (ER) in hormone‐sensitive breast cancer could be harnessed synergistically with the tumor‐migrating effect of porphyrins to selectively deliver estrogen‐porphyrin conjugates into breast tumor cells, and preferentially kill the tu