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Selective Alkoxycarbonylation of A-Ring Precursors of Vitamin D Using Enzymes in Organic Solvents. Chemoenzymatic Synthesis of 1α,25-Dihydroxyvitamin D 3 C-5 A-Ring Carbamate Derivatives 1

✍ Scribed by Ferrero, Miguel; Fernández, Susana; Gotor, Vicente


Book ID
127284057
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
264 KB
Volume
62
Category
Article
ISSN
0022-3263

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Asymmetric synthesis of 1α,25-dihydroxyv
✍ Georges P.J Hareau; Masakazu Koiwa; Fumie Sato 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 113 KB

The A-ring precursor of 1α,25-dihydroxyvitamin D 3 [(E)-4] has been prepared starting from the (5S)-tertbutyldimethylsiloxy-2-cyclohexenone [(S)-1] via eight steps in 19% overall yield, where a catalytic osmium dihydroxylation which sets the stereochemistry of the hydroxyl group at C 1 and a regiose