Selective affinity of the benzodiazepines quazepam and 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand

RTI-4793-14, a new ligand with high affi

RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-[1-(2 thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain

✍ Carl B. Goodman; D. Nigel Thomas; Agu Pert; Betsey Emilien; Jean L. Cadet; F. Iv 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 771 KB

## Abstract [^3^H]TCP, an analog of the dissociative anesthetic phencyclidine (PCP), binds with high affinity to two sites in guinea pig brain membranes, one that is MK‐801 sensitive and one that is not. The MK‐801‐sensitive site (PCP site 1) is associated with NMDA receptors, whereas the MK‐801‐in