Selective adherence of a sucralfate—tetracycline complex to gastric ulcers: Implications for the treatment of Helicobacter pylori
✍ Scribed by Robert A Yokel; Kenneth M. Dickey; Arthur H. Goldberg
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 309 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
The adherence of a sucralfate-tetracycline complex to gastric ulcers and to nearby nonulcer sites was determined in the rabbit antrum. Persistent gastric ulcers were produced by a previously described method. The presence of the complex was assessed 1 and 4 h after dosing. Drug adherence was determined by quantitation of aluminum in stomach wall biopsies. Significantly more aluminum adhered to ulcer sites than to nearby nonulcer sites. Adherence of the complex did not significantly decrease from 1 to 4 h. The complexation of tetracycline to sucralfate did not alter the selective adherence of sucralfate to gastric ulcers, providing a mechanism of ulcer site-selective drug delivery in the treatment of Helicobacter pylori gastric ulcer disease.