The definition of phenotype is a major problem in genetic studies of psychiatric disorders. Most linkage studies in bipolar disorder have defined the phenotype as a dichotomous trait and have usually employed different hierarchical classifications in order to overcome uncertainty resulting from phen
Selection of eating-disorder phenotypes for linkage analysis
β Scribed by Cynthia M. Bulik; Silviu-Alin Bacanu; Kelly L. Klump; Manfred M. Fichter; Katherine A. Halmi; Pamela Keel; Allan S. Kaplan; James E. Mitchell; Alessandro Rotondo; Michael Strober; Janet Treasure; D. Blake Woodside; Vibhor A. Sonpar; Weiting Xie; Andrew W. Bergen; Wade H. Berrettini; Walter H. Kaye; Bernie Devlin
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 130 KB
- Volume
- 139B
- Category
- Article
- ISSN
- 1552-4841
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The problem of linkage analysis of disorders with multiple possible phenotypes (diagnostic spectrum) is considered. A modification is proposed to Ott's [1994] method of down-weighting the contribution of broader diagnoses by reducing penetrance ratios for affected cases. A "robust weighting" strateg
A study was designed to address the relative merits of different sampling strategies for detecting linkage. Genotypes of pedigree members were generated by the use of a single genetic model, and the pedigrees were subdivided into dominantappearing, recessive-appearing , and "interesting" subsets. An
## Objective: The aim of this study was to determine whether temporal patterns of food selection during binges in obese subjects with binge eating disorder (bed) differ from those of patients with bulimia nervosa (bn). ## Method: Ten obese women with bed and 10 weight-matched women without bed ea