The copper complexes of 2-furaldehyde and furan oximes have previously demonstrated potent cytotoxicity, L1210 DNA synthesis inhibition, DNA topoisomerase II inhibition and DNA fragmentation. Currently a series of cobalt metal complexes of 2-furaldehyde oximes were compared with copper complexes of
Selection of Cell Lines in Tissue Culture by the Use of Cytotoxic Antisera
β Scribed by DEFENDI, V.; KAMRIN, A. A.; COLTER, J. S.
- Book ID
- 109598758
- Publisher
- Nature Publishing Group
- Year
- 1958
- Tongue
- English
- Weight
- 449 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0028-0836
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The copper complexes of furan oxime derivatives were found to be potent cytotoxic agents in both murine and human tissue cultured cell lines which were suspended as well as solid tumors. Mode of action studies in murine L1210 lymphoid leukemia cells showed that the compounds suppressed DNA, RNA and
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