Selection of 3LL tumor subline resistant to natural effector cells concomitantly selected for increased metastatic potency

Differences in the metastatic potential

Differences in the metastatic potential of two sublines of tumor 3LL selected for resistance to natural NK-like effector cells

✍ Pnina Brodt; Michael Feldman; Shraga Segal 📂 Article 📅 1983 🏛 Springer-Verlag 🌐 English ⚖ 527 KB

Normal syngeneic spleen cells were found to inhibit the local growth of the Lewis lung carcinoma (3LL) when injected together with the tumor cells" at a ratio of lO0 : 1 (spleen to tumor cells). The repeated injection of the tumor cells together with spleen cells enventually led to the selection of