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Selection for β2-microglobulin mutation in mismatch repair-defective colorectal carcinomas

✍ Scribed by David C. Bicknell; Loukas Kaklamanis; Richard Hampson; Walter F. Bodmer; Peter Karran


Book ID
114319665
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
88 KB
Volume
6
Category
Article
ISSN
0960-9822

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## Mutations within microsatellite sequences, consisting of additions or deletions of repeat units, are known as the replication/repair error positive (RER+) phenotype or micorsatellite instability (MI). Microsatellite instability has been demonstrated in hereditary and sporadic colorectal carcino