𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Selection and characterization of nuclear mutations affecting mitochondria in Paramecium

✍ Scribed by Ruiz, Françoise ;Adoutte, André

Publisher
Springer
Year
1978
Tongue
English
Weight
721 KB
Volume
162
Category
Article
ISSN
0026-8925

No coin nor oath required. For personal study only.

✦ Synopsis

A screening method, based upon resistance to a tetrazolium salt (TTC), is described which permitted the isolation in Paramecium of 28 mutants resistant to TTC. These mutants displayed various defects in mitochondrial functions (cytochromic content cyanide insensitive respiration). Some mutations seemed to affect directly the respiration chain while others seemed to cause indirect modifications, possibly altering mitochondrial protein synthesis. Genetic analysis of four mutants showed in all that the resistance to TTC was of nuclear origin.

📜 SIMILAR VOLUMES

Molecular analysis and characterization
Molecular analysis and characterization of nine novel CTSK mutations in twelve patients affected by pycnodysostosis
✍ Michela Donnarumma; Stefano Regis; Barbara Tappino; Camillo Rosano; Stefania Ass 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB

Molecular characterization of twelve unrelated patients affected by the autosomal recessive osteosclerotic skeletal dysplasia, Pycnodysostosis (cathepsin k deficiency), revealed 11 different genotypes. The mutational profile consisted of 12 different mutations, including nine previously unreported o