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Selection and characterization of an internalizing epidermal-growth-factor-receptor antibody

✍ Scribed by Xiaorong Zhao; Wentao Dai; Limin Cao; Huifen Zhu; Yihan Yu; Qing Ye; Min Wang; Wei Dai; Ping Lei; Guanxin Shen


Book ID
111718121
Publisher
Portland Press
Year
2007
Tongue
English
Weight
296 KB
Volume
46
Category
Article
ISSN
0885-4513

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Recent studies demonstrated that tumors overexpressing the epidermal growth factor receptor (EGF-R, erbB-1) are associated with poor clinical outcome. This led to the development of a variety of monoclonal antibodies targeting the extracellular domain of this receptor tyrosine kinase. The aim of our