Seizures induced by carbachol, morphine, and leucine-enkephalin: A comparison

✍ Scribed by Dr O. Carter Snead III

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 647 KB
• Volume: 13
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410130412

✦ Synopsis

The electrical, behavioral, and pharmacological properties of seizures induced by morphine, leucine-enkephalin, and the muscarinic cholinergic agonist carbachol were examined and compared. Low-dose carbachol given intracerebroventricularly (ICV) produced seizures similar electrically to those produced by ICV morphine and leucineenkephalin, although there was some difference in site of subcortical origin of onset. Carbachol and morphine were similar i n that they had the same anticonvulsant profile, produced similar behavioral changes, caused generalized absence seizures i n low doses and generalized convulsive seizures i n high doses, and were capable of chemical kindling. However, opiate-induced seizures were not overcome by cholinergic antagonists, nor were carbachol seizures blocked by opiate antagonists. These data suggest that there may be a common noncholinergic, nonopiatergic system involved i n mediating carbachol-and morphine-induced seizures but not enkephalin seizures.

Snead O C 111: Seizures induced by carbachol, morphine, and leucine-enkephalin: a comparison.