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Competition of nitroxyl contrast agents

Competition of nitroxyl contrast agents as an in vivo tissue redox probe: Comparison of pharmacokinetics by the bile flow monitoring (BFM) and blood circulating monitoring (BCM) methods using X-band EPR and simulation of decay profiles

✍ Aya Okajo; Ken-ichiro Matsumoto; James B. Mitchell; Murali C. Krishna; Kazutoyo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 592 KB

## Abstract Nitroxyl radicals used as tissue redox‐sensitive contrast agents in electron paramagnetic resonance (EPR) and/or NMR imaging should satisfy the following two conditions: 1) the molecules disperse into tissues rapidly, and 2) paramagnetic loss occurs by simple reduction of the radical. T