Seeing double: Crystal structures of the
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James H. Naismith; Barbara J. Brandhuber; Tracey Q. Devine; Stephen R. Sprang
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Article
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1996
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John Wiley and Sons
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English
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The crystal structure of the extracellular domain of the type I tumor necrosis factor receptor (sTNF-Rl) has been determined to 2.25 di at pH 7.5. We have also solved the structure of sTNF-Rl at pH 3.7. sTNF-R1 is an elongated molecule consisting of a linear combination of four cysteine-rich motifs.