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Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo

✍ Scribed by Miriam Kolko; Torben Bruhn; Thomas Christensen; Michel Lazdunski; Gérard Lambeau; Nicolas G. Bazan; Nils H. Diemer


Book ID
117478084
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
114 KB
Volume
274
Category
Article
ISSN
0304-3940

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Secreted phospholipase A2 potentiates gl
✍ Mark A. DeCoster; Gerard Lambeau; Michel Lazdunski; Nicolas G. Bazan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 762 KB

## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamate‐induced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe