Secretory expression of the fusion protein composed of human IL-2 and PreS antigen of hepatitis B virus in mammalian cells
β Scribed by Zhangguo Chen; Dalong Ma; Jing Wang; Yingmei Zhang; Yong Yuan; Wenling Han; Hongtao Liu
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 216 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1001-6538
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina
## Abstract Therapeutic proteins like human interferon Ξ±2 generally possess short serum halfβlives due to their small size, hence rapid renal clearance, and susceptibility to serum proteases. Chemical derivatization, such as addition of polyethylene glycol (PEG) groups overcomes both problems, but