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Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

✍ Scribed by Zofia von Marschall; Larry W. Fisher


Book ID
116300716
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
545 KB
Volume
400
Category
Article
ISSN
0006-291X

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## Abstract Canonical Wnt signaling (β‐catenin/TCF) has emerged as a key regulator of skeletogenesis. In this study, chondrogenesis is examined in a mouse model in which the Wnt antagonist secreted frizzled related protein 1 (sFRP1) is non‐functional and results in a high bone mass phenotype and ac