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Secondary sphingolipid accumulation in a macrophage model of Gaucher disease

✍ Scribed by Leanne K. Hein; Peter J. Meikle; John J. Hopwood; Maria Fuller


Book ID
116988055
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
207 KB
Volume
92
Category
Article
ISSN
1096-7192

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Gaucher disease is the most common lysosomal glycosphingolipid storage disease; decreased activity of glucosylceramide P-glucosidase (GCase) results in the accumulation of glucocerebroside (GlcCer) in macrophage-derived cells. The most devastating types of Gaucher disease also involve neuronopatholo