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Secondary near-tetraploidy with double der(15)t(15;17) in acute promyelocytic leukemia in relapse

✍ Scribed by Yuriko Morita; Asami Takahashi; Koh Yamamoto; Tohru Miki; Naomi Murakami; Osamu Miura

Book ID: 113512297
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 398 KB
Volume: 149
Category: Article
ISSN: 0165-4608
DOI: 10.1016/j.cancergencyto.2003.07.009

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## Abstract The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different __PML__ breakpoint cluster regions (bcr) on chromosome 15 and within __RARA__ intron 2 on chromosome 17; however, the precise mechanism by whic