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Secondary Metabolites from the Fungus Chaetomium brasiliense

✍ Scribed by Guo-You Li; Bo-Gang Li; Tao Yang; Guang-Ye Liu; Guo-Lin Zhang

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
209 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new depsidones, mollicellins I and J (1 and 2, resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin (3), along with six known compounds, 4–9, were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated based on spectroscopic analysis. Mollicellins I and H (5) exhibited significant growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines with GI~50~ values between 2.5–8.6β€…ΞΌg/ml.

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