## Abstract We investigated the risk of second malignancies among 29,511 survivors of germβcell testicular cancer recorded in 13 cancer registries. Standardized incidence ratios (SIRs) were estimated comparing the observed numbers of second malignancies with the expected numbers obtained from sexβ,
Secondary malignancies among nonseminomatous germ cell tumor cancer survivors
β Scribed by Karim Chamie; Eric A. Kurzrock; Christopher P. Evans; Mark S. Litwin; Theresa M. Koppie; Sandra L. Wootton-Gorges; John M. Boone; Primo N. Lara Jr; Ralph W. deVere White
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 442 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
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Patients cured of a malignant germ-cell tumor are at a significantly increased relative risk (RR, 1.3-2.1) of developing a new malignancy, the most frequent second cancer being a new germ-cell cancer. The exact role of modern treatment of germ-cell malignancies as an etiological factor of a subseque
## Abstract Hypermethylation of tumorβsuppressor genes has been implicated in the pathogenesis of human cancers. Although a growing number of genes showing hypermethylation is being reported in human cancer, methylation profiles of tumorβrelated genes in testicular neoplasms have not been well eluc