Secondary bacterial infection in plasma endotoxin levels and the acute-phase response of mice infected with Trypanosoma brucei brucei

Neuronal activity and transcription of p

Neuronal activity and transcription of proinflammatory cytokines, IκBα, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei

✍ Sébastien Brochu; Martin Olivier; Serge Rivest 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 730 KB

Trypanosoma brucei brucei (Tbb) infection is a model of chronic immune response associated with severe neurological disorders believed to lead to coma and death. We hypothesized that exaggerated production of proinflammatory molecules within the cental nervous system (CNS) may be involved in the eti