Secondary antithyroid action of drugs in relation to structure
โ Scribed by J. Buxeraud; A. C. Absil; C. Raby
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 324 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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โฆ Synopsis
Molecular interactions between iodine and disulfiram, clomethiazole, and tolnaftate were investigated by electron spectroscopy. Iodine forms charge transfer complexes with these molecules, with 1:1 stoichiometry and of the n-sigma type. The formation constants were compared with those obtained with antithyroid molecules. Only disulfiram appears to have any effect on the intrathyroid cycle of iodine.
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