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Second-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian women

โœ Scribed by Yung Hang Lam; Mary Hoi Yin Tang; Lawrence Chang Hung Tang; Chin Peng Lee; Philip Kin Hoi Ho

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
56 KB
Volume
17
Category
Article
ISSN
0197-3851

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โœฆ Synopsis

Maternal urinary gonadotrophin peptide (UGP) was recently found to be elevated in second-trimester Down syndrome pregnancies. There is controversy about its screening efficacy. Data in the Asian population are scanty. We measured the UGP levels in 29 Down syndrome pregnancies and 297 controls and expressed them as a ratio of the urine creatinine concentration. Median UGP MOM was elevated to 3.44 (95 per cent confidence interval 1.99-5.13) in cases, compared with controls. UGP values were widely scattered in cases and controls with extensive overlap such that only 35 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. The data of the present study and previous reports show that there is a wide variability of gestation-specific UGP median values. UGP alone does not appear to be an effective screening marker for fetal Down syndrome.

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