Second trimester maternal serum hCG level in an Asian population: Normal reference values by ultrasound dating
✍ Scribed by Hei-Jen Jou; Ming-Kwang Shyu; Jin-Chung Shih; Mei-Yang Chang; Chin-Chuan Lim; Chau-Yang Tzeng; Shih-Ming Chen; Fon-Jou Hsieh
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 122 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1057-0802
No coin nor oath required. For personal study only.
✦ Synopsis
Objective: To establish normative data of maternal serum chorionic gonadotropin (hCG) during the second trimester in an Asian population. Methods: We measured the maternal serum hCG levels in 17,955 normal singleton pregnancies between 15 and 21 weeks of gestation. The gestation age was estimated by measurement of fetal biparietal distance (BPD) in all cases. Median values of hCG at various gestational weeks were calculated and the values of hCG were converted to multiple of median (MoM). The incidences of low MoM value and high MoM value were also calculated.
Results:
The mean and median values of hCG were 57,153 mIU/ml and 50,120 mIU/ml, respectively, at 15 weeks of gestation and then decreased to 30,898 mIU/ml and 26,226 mIU/ml, respectively, at 21 weeks. We found 8.6% and 9.4% of normal singleton pregnancies have hCG MoM values Ͼ2.0 MoM and Ͻ0.5 MoM, respectively. Conclusions: Our report provides a normal reference data of second trimester maternal hCG levels by ultrasound dating in an Asian population.