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SECOND-TRIMESTER HYDROPS FETALIS IN PREGNANCIES AFFECTED BY HOMOZYGOUS α-THALASSAEMIA-1

✍ Scribed by YUNG HANG LAM; ARABINDA GHOSH; MARY HOI YIN TANG; CHIN PENG LEE; SAI YUEN SIN

Book ID
101236054
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
187 KB
Volume
17
Category
Article
ISSN
0197-3851

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✦ Synopsis

Homozygous alpha-thalassaemia-1 is the commonest cause of hydrops fetalis in South-East Asia. Ultrasonographic features of hydrops fetalis were said to be evident only after 20 weeks of gestation. We studied 111 pregnancies at risk of homozygous alpha-thalassaemia-1 at 12-14 gestational weeks and 101 pregnancies at 17-18 weeks by abdominal ultrasound examination. Ultrasonographic features of hydrops fetalis were seen in 3 out of 44 pregnancies affected by homozygous alpha-thalassaemia-1 at 12-14 weeks [7 per cent; 95 per cent confidence interval (CI) 1-19 per cent] and in 7 out of 21 affected pregnancies at 17-18 weeks (33 per cent; 95 per cent CI 15-57 per cent). In conclusion, homozygous alpha-thalassaemia-1 can cause hydrops fetalis in the early second trimester. It should constitute one of the differential diagnoses in the work-up of second-trimester hydrops fetalis.

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EARLY ULTRASOUND PREDICTION OF PREGNANCI
EARLY ULTRASOUND PREDICTION OF PREGNANCIES AFFECTED BY HOMOZYGOUS α-THALASSAEMIA-1
✍ YUNG HANG LAM; ARABINDA GHOSH; MARY HOI YIN TANG; CHIN PENG LEE; SAI YUEN SIN 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB

Homozygous -thalassaemia-1 is conventionally diagnosed by invasive testing on all at-risk pregnancies. We evaluated the diagnostic efficacy of non-invasive abdominal ultrasonographic cardiothoracic ratio measurement in 62 pregnancies at 13-14 weeks and 75 pregnancies at 17-18 weeks. This performed b