Second toxicity testing programme for CFC producers

Programme for alternative fluorocarbon t

Programme for alternative fluorocarbon toxicity testing

📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 121 KB

Significance of the dog as ‘second anima

Significance of the dog as ‘second animal species’ in toxicity testing for establishing the lowest ‘no-toxic-effect level’

✍ L. M. Appelman; V. J. Feron 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 618 KB

The toxicity data of 66 compounds adequately tested in the rat (as 'prime animal species') and in the dog (as 'second animal species') were studied to find out for how many of these compounds the study in dogs led to a lower 'no-toxic-effect level' (NTEL) than that found in the rat. From a quantitat