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Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx

✍ Scribed by Karen Lin; Snehal G. Patel; Pen Yuan Chu; Jeannette M. S. Matsuo; Bhuvanesh Singh; Richard J. Wong; Dennis H. Kraus; Ashok R. Shaha; Jatin P. Shah; Jay O. Boyle

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 276 KB
Volume: 27
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20272

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

We aimed to identify patterns and predictors of second primary malignancy (SPM) of the aerodigestive tract (SPMADT) in patients with squamous cell carcinoma of the oral cavity (SCCOC) and larynx (SCCL).

Methods.

One thousand two hundred fifty‐seven patients from two existing databases were studied: 595 with SCCOC (1986–1995) and 662 with SCCL (1984–1998). The primary endpoint of interest was development of SPMADT, defined as a second primary neoplasm of the head and neck, esophagus, or lung.

Results.

The 5‐year SPMADT rate was 8% in the SCCL versus 10% in the SCCOC subgroup. Lung SPM was more common in the SCCL group; head and neck SPM was more common in the SCCOC group. Smokers had a fivefold increased risk, whereas alcohol use was associated with a twofold increased risk of SPMADT.

Conclusions.

The rates of SPMADT after treatment of SCCOC and SCCL are comparable, but the patterns are different. Smoking and alcohol use are independent predictors of SPMADT development. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005

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