Second Generation of cycloSal-Pronucleotides with Esterase-Cleavable Sites: The “Lock-In”-Concept

Second-Generation cycloSal-d4TMP Pronucl

Second-Generation cycloSal-d4TMP Pronucleotides Bearing Esterase-Cleavable Sites — The “Trapping” Concept

✍ Chris Meier; Christian Ducho; Henning Jessen; Dalibor Vukadinović-Tenter; Jan Ba 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

## Abstract An extension of the __cyclo__Sal‐pronucleotide approach is presented. Attachment of an enzyme‐cleavable ester/acylal group to the __cyclo__Sal‐d4TMP triesters should allow these compounds to be trapped intracellularly after cleavage. The ester/acylal groups were introduced in the 3‐ or