A mild, large-scale synthesis of 1,3-cyc
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Evan A. Sims; Cole A. DeForest; Kristi S. Anseth
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Article
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2011
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Elsevier Science
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French
β 264 KB
We report the large-scale synthesis of 1,3-cyclooctanedione in five steps with 29% yield. This molecule is a synthetic precursor to difluorinated cyclooctyne, which participates in a bioorthogonal copper-free click reaction with azides. The final step demonstrates the first successful application of