Second generation benzannulation reactions: Sugar-derived Fischer chlorocarbene complexes in organic synthesis

✍ Scribed by Michael.R. Hallett; James E. Painter; Peter Quayle; Dean Ricketts; Prakash Patel

• Book ID: 104259042
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 122 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00315-3

✦ Synopsis

The facile melallation of 2-chloroglucal derivatives 8 and ! ! affords ready access to the corresponding Fischer catbene complexes 1 0 and 1 3. Carbene complexes i 0 and 13 undergo ben,~anulation reactions with acetylenes to previde functionalised benzopyrans in moderate overall yields.