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Second-Chance Rearrangement Route to Novel 5(6)-syn,anti-Difunctional 2-Azabicyclo[2.1.1]hexanes.

โœ Scribed by Grant R. Krow; Guoliang Lin; Fang Yu; Philip E. Sonnet


Publisher
John Wiley and Sons
Year
2003
Weight
119 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Novel Conversion of Perfluoro(2,6-dimethyl-1-azacyclohexene) to 3,3,4,4,5-Pentafluoro-2,6-diphenyl-2,6-bis (trifluoromethyl)-1azabicyclo[3.1.0]hexane. -Treatment of perfluoro-azacyclohexene (I) with 2 equiv. of phenyllithium (V) in a cyclohexane/Et 2 O mixture provides access to azabicyclohex