Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers
β Scribed by Forgacs, Eva; Wren, Jonathan D; Kamibayashi, Craig; Kondo, Masashi; Xu, Xie L; Markowitz, Sanford; Tomlinson, Gail E; Muller, Carolyn Y; Gazdar, Adi F; Garner, Harold R
- Book ID
- 110064506
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 156 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In the present study, leukocyte DNA from 143 patients with familial clustering of breast and/or ovarian cancer and tumour DNA from 96 breast carcinomas were screened for base mutations in the estrogen receptor gene (ESR). Three patients with a family history of cancer were carrying a Gly160Cys germl
## Communicated by Albert de la Chapelle Mutation analysis of complex genes without hotspots for sequence variations, such as BRCA1, is time-consuming and expensive. Of all currently available methods, direct sequencing has the highest sensitivity, but also the highest costs. Other techniques, such